{"id":4388,"date":"2023-10-23T13:02:17","date_gmt":"2023-10-23T13:02:17","guid":{"rendered":"http:\/\/rnce.inserm.fr\/hope-epi-ccop\/etiological-research-geocap\/"},"modified":"2024-05-28T13:27:39","modified_gmt":"2024-05-28T13:27:39","slug":"etiological-research-geocap","status":"publish","type":"page","link":"https:\/\/rnce.inserm.fr\/en\/hope-epi-ccop\/etiological-research-geocap\/","title":{"rendered":"Etiological research GEOCAP"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4388\" class=\"elementor elementor-4388 elementor-69\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9185a63 e-flex e-con-boxed e-con e-parent\" data-id=\"9185a63\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e1159e6 e-con-full e-flex e-con e-child\" data-id=\"e1159e6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f4eb529 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"f4eb529\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<h3 align=\"justify\">GEOCAP program<\/h3>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7d478f2 elementor-widget elementor-widget-text-editor\" data-id=\"7d478f2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p align=\"justify\">The overall aim of the GEOCAP program is to study the influence of environmental exposures on childhood cancer risk, based on the spatial coordinates of the place of residence.<\/p>\n<p align=\"justify\">The program is based on 2 ongoing national case-control studies integrated into the CCOP, GEOCAP-Diag, which began in 2002 and focuses on address of residence at diagnosis, and GEOCAP-Birth, which began in 2010 and focuses on address of residence at birth. Each year, the GEOCAP-Diag control group includes around 5,000 addresses representative of the French paediatric population. The GEOCAP-Birth control group includes around 2,000 addresses per year, representative of French births.<\/p>\n<p align=\"justify\">All addresses are geocoded in Lambert 93 coordinates using information from IGN&#8217;s BD Adresse\u00ae database (version 2.2), supplemented by information from Google Streetview, G\u00e9oportail, Google Maps, the land registry and Mappy.fr for the most complex situations. Geocoding is carried out simultaneously for cases and witnesses by RetailSonar, which has the addresses to the exclusion of any other information.<\/p>\n<p align=\"justify\">The children&#8217;s contact details, supplemented by information on age, sex, year of inclusion and diagnosis where applicable, are processed in a geographic information system to assign the estimated environmental exposures at their address to each individual.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-207048d e-con-full e-flex e-con e-child\" data-id=\"207048d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6d55d11 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"6d55d11\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Regulatory aspects<\/h3>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-acb628a elementor-widget elementor-widget-text-editor\" data-id=\"acb628a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>CNIL National Registry of Malignant Haemopathies in Children (no. 998198) and National Registry of Solid Tumours in Children (no. 900183)<\/p>\n<p>Geocap notice Ref GD\/CE072347. GEOCAP-AGRI receipt 2077682 v 0.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e2692ad elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"e2692ad\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Financing<\/h3>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6760106 elementor-widget elementor-widget-text-editor\" data-id=\"6760106\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Public Health France, National Agency for Food, Environmental and Occupational Health and Safety (ANSES), National Research Agency (ANR) &#8211; Future Investment HOPE-EPI, ARC Foundation for Cancer Research, National Cancer Institute (INCa), Canceropole of \u00cele-de-France, EDF, Pfizer Foundation.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56c4789 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"56c4789\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3>Principal investigators  <\/h3>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31c0471 elementor-widget elementor-widget-text-editor\" data-id=\"31c0471\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Jacqueline Clavel and St\u00e9phanie Goujon<\/p>\n<p>IRSN, RTE, Sant\u00e9 publique France, INRAE, IRSET, SWIS TPH, AIR PARIF, ATMO France<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e0c77c9 e-flex e-con-boxed e-con e-parent\" data-id=\"e0c77c9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0ab73d8 elementor-widget elementor-widget-html\" data-id=\"0ab73d8\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<script>\r\njQuery(document).ready(function($) {\r\nvar delay = 100; setTimeout(function() {\r\n$('.elementor-tab-title').removeClass('elementor-active');\r\n $('.elementor-tab-content').css('display', 'none'); }, delay);\r\n});\r\n<\/script>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e2e941 elementor-widget elementor-widget-accordion\" data-id=\"3e2e941\" data-element_type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 05-08-2024 *\/\n.elementor-accordion{text-align:start}.elementor-accordion .elementor-accordion-item{border:1px solid #d5d8dc}.elementor-accordion .elementor-accordion-item+.elementor-accordion-item{border-top:none}.elementor-accordion .elementor-tab-title{margin:0;padding:15px 20px;font-weight:700;line-height:1;cursor:pointer;outline:none}.elementor-accordion .elementor-tab-title .elementor-accordion-icon{display:inline-block;width:1.5em}.elementor-accordion .elementor-tab-title .elementor-accordion-icon svg{width:1em;height:1em}.elementor-accordion .elementor-tab-title .elementor-accordion-icon.elementor-accordion-icon-right{float:right;text-align:right}.elementor-accordion .elementor-tab-title .elementor-accordion-icon.elementor-accordion-icon-left{float:left;text-align:left}.elementor-accordion .elementor-tab-title .elementor-accordion-icon .elementor-accordion-icon-closed{display:block}.elementor-accordion .elementor-tab-title .elementor-accordion-icon .elementor-accordion-icon-opened,.elementor-accordion .elementor-tab-title.elementor-active .elementor-accordion-icon-closed{display:none}.elementor-accordion .elementor-tab-title.elementor-active .elementor-accordion-icon-opened{display:block}.elementor-accordion .elementor-tab-content{display:none;padding:15px 20px;border-top:1px solid #d5d8dc}@media (max-width:767px){.elementor-accordion .elementor-tab-title{padding:12px 15px}.elementor-accordion .elementor-tab-title .elementor-accordion-icon{width:1.2em}.elementor-accordion .elementor-tab-content{padding:7px 15px}}.e-con-inner>.elementor-widget-accordion,.e-con>.elementor-widget-accordion{width:var(--container-widget-width);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-6521\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-6521\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-angle-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-angle-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Crop proximity and childhood cancers - GEOCAP-Agri<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-6521\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-6521\"><p><strong>Objective<\/strong>: to study the risk of cancer in children living near crops<\/p><p><strong>Financing <\/strong> : ANSES, INCa-PEDIAC<\/p><p><strong>Collaborations<\/strong>: Sant\u00e9 publique France<\/p><p><strong><em>\u279d Exposure at time of diagnosis, period 2006-2013<\/em><\/strong><\/p><p>Main results: increased risk of leukemia and, to a lesser extent, neuroblastoma in children living near vineyards:<\/p><p>Mancini M, Hemon D, de Crouy-Chanel P, Guldner L, Faure L, Clavel J, Goujon S. Association between Residential Proximity to Viticultural Areas and Childhood Acute Leukemia Risk in Mainland France: GEOCAP Case-Control Study, 2006-2013.Environ Health Perspect, 2023;131(10):107008<\/p><p>Awounou D, Mancini M, Lacour B, de Crouy-Chanel P, Aerts I, Minard-Colin V, Schleiermacher G, Verschuur A, Guissou S, Desandes E, Guldner L, Clavel J, Goujon S. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37865323\/\" target=\"_blank\" rel=\"noopener\">Residential proximity to vines and risk of childhood embryonal tumours in France &#8211; GEOCAP case-control study, 2006-2013<\/a>.Environ Res. 2023 Oct 19:117417.<\/p><p>Coste A, Goujon S, Faure L, Hemon D, Clavel J. Agricultural crop density in the municipalities of France and incidence of childhood leukemia: An ecological study. Environ Res. 2020;187:109517.<\/p><p align=\"justify\">\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-6522\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-6522\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-angle-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-angle-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Proximity to roads, air pollution and acute childhood leukemia<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-6522\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-6522\"><p><strong>Objective:<\/strong> study the risk of childhood cancer in relation to traffic-related air pollutants<\/p><p><strong>Financing :<\/strong> ANSES, INCa-PEDIAC<\/p><p><strong>Collaborations:<\/strong> IRSET UMRS Inserm 1085, AirParif, Swiss TPH, Cohorte CONSTANCES, AtmoFrance<\/p><p><em><strong>\u279d Exposure at time of diagnosis, period 2002-2020 &#8211; GEOCAP-Air<\/strong><\/em><\/p><p>In progress<\/p><p><em><strong>\u279d Exposure at birth, period 2010-2015<\/strong><\/em><\/p><p>Main results: increased risk of acute leukemia with air pollution indicators (especially PM2.5) &#8211; no increased risk near roads<\/p><p>(article in preparation)<\/p><p><em><strong>\u279d Exposure at time of diagnosis, period 2002-2007<\/strong><\/em><\/p><p>Main results: increased risk of acute myeloblastic leukemia in children living near high-traffic roads<\/p><p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26377958\" target=\"_blank\" rel=\"noopener\">Houot J, Marquant F, Goujon S, Faure L, Honor\u00e9 C, Roth MH, H\u00e9mon D, Clavel J. Residential proximity to heavy-traffic roads, benzene exposure, and childhood leukemia-the GEOCAP study, 2002-2007. Am J Epidemiol 2015; 182(8):685-93.<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-6523\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-6523\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-angle-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-angle-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Naturally-occurring ionizing radiation and childhood cancer<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-6523\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-6523\"><p><strong>Objective :<\/strong> to study the risk of cancer in children as a function of variations in exposure to radon and telluric gamma rays of natural origin.<\/p><p><strong>Financing :<\/strong> ANSES, ARC, INCa, ANR<\/p><p><strong>Collaborations:<\/strong> IRSN<\/p><p><em><strong>\u279d Exposure at time of diagnosis<\/strong><\/em><\/p><p>Main results: no association between the risk of leukemia and the level of exposure to naturally-occurring ionizing radiation in the commune of residence at diagnosis &#8211; doubt about a possible link between exposure to naturally-occurring gamma radiation and pilocytic astrocytomas.<\/p><p><a href=\"https:\/\/ehp.niehs.nih.gov\/doi\/full\/10.1289\/EHP296\" target=\"_blank\" rel=\"noopener\">Demoury C, Marquant F, Ielsch G, Goujon S, Debayle C, Faure L, Coste A, Laurent O, Guillevic J, Laurier D, H\u00e9mon D, Clavel J. Residential Exposure to Natural Background Radiation and Risk of Childhood Acute Leukemia in France, 1990-2009.<\/a> Environ Health Perspect. 2017 Apr;125(4):714-720.<\/p><p>Berlivet J, Hemon D, Clero E, Ielsch G, Laurier D, Guissou S, Lacour B, Clavel J, Goujon S. Ecological association between residential natural background radiation exposure and the incidence rate of childhood central nervous system tumors in France, 2000-2012. J Environ Radioact. 2020;211:106071.<\/p><p><em><strong>\u279d Exposure at the time of birth<\/strong><\/em><\/p><p>Main results: no association between the risk of leukemia and the level of exposure to naturally occurring ionizing radiation in the commune of residence at birth.<\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33895630\/\" target=\"_blank\" rel=\"noopener\">Berlivet J, Hemon D, Clero E, Ielsch G, Laurier D, Faure L, Clavel J, Goujon S. Residential exposure to natural background radiation at birth and risk of childhood acute leukemia in France, 1990-2009. J Environ Radioact. 2021;233:106613.<\/a><\/p><p>Working with IRSN<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-6524\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-6524\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-angle-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-angle-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Proximity to high-voltage power lines, extremely low-frequency magnetic fields<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-6524\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-6524\"><p><strong>Objective :<\/strong> to study the risk of leukemia in children living in the immediate vicinity of high-voltage power lines, and to investigate the influence of the magnetic fields generated by these lines as the current passes through them.<\/p><p><strong>Financing :<\/strong> ANSES, ARC, INCa, ANR<\/p><p><strong>Collaborations:<\/strong> RTE<\/p><p><em><strong>\u279d Extremely low-frequency magnetic fields and the risk of acute childhood leukemia (2002-2013)<\/strong><\/em><\/p><p>In progress<\/p><p><em><strong>\u279d Proximity to high-voltage power lines at diagnosis and acute childhood leukemia (2002-2007)<\/strong><\/em><\/p><p>Main results: slight increase in the risk of leukemia in children living within 50 m of an extra-high-voltage power line<\/p><p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23558899?dopt=abstract\" target=\"_blank\" rel=\"noopener\">Sermage-Faure C, Demoury C, Rudant J, Goujon-Bellec S, Guyot-Goubin A, Deschamps F, Hemon D, Clavel J. Childhood leukemia close to high voltage power lines &#8211; the Geocap study, 2002-2007. Br J Cancer, 2013;108(9):1899-906.<\/a><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29808013\/\" target=\"_blank\" rel=\"noopener\">Amoon AT, Crespi CM, Ahlbom A, Bhatnagar M, Bray I, Bunch KJ, Clavel J, Feychting M, Hemon D, Johansen C, Kreis C, Malagoli C, Marquant F, Pedersen C, Raaschou-Nielsen O, Roosli M, Spycher BD, Sudan M, Swanson J, Tittarelli A, Tuck DM, Tynes T, Vergara X, Vinceti M, Wunsch-Filho V, Kheifets L. Proximity to overhead power lines and childhood leukaemia: an international pooled analysis. Br J Cancer. 2018;119(3):364-73.<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-6525\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-6525\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-angle-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-angle-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Environmental UV exposure and acute childhood leukemia<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-6525\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-6525\"><p><strong>Objective :<\/strong> to study the influence of UV exposure on the risk of childhood leukemia.<\/p><p><strong>Financing :<\/strong> ANSES, ARC, INCa, ANR<\/p><p><strong>Collaborations:<\/strong><br \/>IPRI<\/p><p><br \/><strong>Main results:<\/strong> suggestions of an increased risk of leukemia in children living in municipalities with the highest UV exposure<\/p><p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28770363\" target=\"_blank\" rel=\"noopener\">Coste A, H\u00e9mon D, Orsi L, Boniol M, Dor\u00e9 JF, Faure L, Clavel J, Goujon S. Residential exposure to ultraviolet light and risk of precursor B-cell acute lymphoblastic leukemia: assessing the role of individual risk factors, the ESCALE and ESTELLE studies. Cancer Causes Control. 2017 Oct;28(10):1075-1083.<\/a><\/p><p>Coste A, Goujon S, Boniol M, Marquant F, Faure L, Dore JF, Hemon D, Clavel J. Residential exposure to solar ultraviolet radiation and incidence of childhood hematological malignancies in France.Cancer Causes Control, 2015;26(9):1339-49 PMID:26169300.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-6526\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"button\" aria-controls=\"elementor-tab-content-6526\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><i class=\"fas fa-angle-right\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><i class=\"fas fa-angle-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Proximity to nuclear power plants and acute childhood leukemia<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-6526\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"region\" aria-labelledby=\"elementor-tab-title-6526\"><p><br \/><strong>Objective :<\/strong> to study the risk of leukemia in children living within 20 km of a nuclear power plant, and the influence of exposure to radioactive releases<\/p><p><strong>Financing :<\/strong> ANSES, ARC, INCa, ANR<\/p><p><strong>Collaborations:<\/strong> IRSN<\/p><p><strong>Main results:<\/strong> increased risk of acute leukemia in children living within 5 km of a nuclear power plant, but no association with radioactive releases from the plants<\/p><p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22223329?dopt=abstract\" target=\"_blank\" rel=\"noopener\">Sermage-Faure C, Laurier D, Goujon-Bellec S, Chartier M, Guyot-Goubin A, Rudant J, H\u00e9mon D, Clavel J. Childhood leukemia around French nuclear power plants&#8211;theGeocap study, 2002-2007. Int J Cancer 2012;131(5):E769-80.\u00a0<\/a><\/p><p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22223329\" target=\"_blank\" rel=\"noopener\">Clavel J, Sermage-Faure C, Goujon-Bellec S, Rudant J, Guyot-Goubin A, Chartier M, Laurier D, H\u00e9mon D. Childhood leukemia around French nuclear power plants &#8211; the Geocap study, 2002-2007 &#8211; responses to letters. Int J Cancer 2012.<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>GEOCAP program The overall aim of the GEOCAP program is to study the influence of environmental exposures on childhood cancer risk, based on the spatial coordinates of the place of residence. The program is based on 2 ongoing national case-control studies integrated into the CCOP, GEOCAP-Diag, which began in 2002 and focuses on address of [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":5250,"parent":3345,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-4388","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/pages\/4388","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/comments?post=4388"}],"version-history":[{"count":10,"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/pages\/4388\/revisions"}],"predecessor-version":[{"id":5400,"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/pages\/4388\/revisions\/5400"}],"up":[{"embeddable":true,"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/pages\/3345"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/media\/5250"}],"wp:attachment":[{"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/media?parent=4388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}