{"id":4458,"date":"2023-11-21T13:36:03","date_gmt":"2023-11-21T13:36:03","guid":{"rendered":"http:\/\/rnce.inserm.fr\/non-classifiee\/escale-and-estelle-case-control-studies\/"},"modified":"2023-11-21T13:36:03","modified_gmt":"2023-11-21T13:36:03","slug":"escale-and-estelle-case-control-studies","status":"publish","type":"post","link":"https:\/\/rnce.inserm.fr\/en\/research-and-results\/escale-and-estelle-case-control-studies\/","title":{"rendered":"ESCALE and ESTELLE case-control studies"},"content":{"rendered":"<p>Both surveys were conducted a few years apart with similar protocols.<\/p>\n<p><strong>Objectives<\/strong><\/p>\n<p>The objective of these two studies was:<\/p>\n<ul>\n<li>to study the influence, on the risk of cancer in children, of the course of pregnancy, the characteristics of the child at birth, the child&#8217;s environment in utero or during childhood, and their lifestyle.<\/li>\n<li>to identify genetic predisposing factors.<\/li>\n<li>to investigate potential interactions between genetic factors and environmental factors.<\/li>\n<\/ul>\n<p><strong>Methods<\/strong><\/p>\n<ul>\n<li>Cases were identified in pediatric oncology services; controls were recruited from telephone directories while respecting age, sex, and household size quotas.<\/li>\n<li>The mothers of cases and controls were interviewed by telephone.<\/li>\n<li>Blood or saliva samples were collected with informed consent.<\/li>\n<\/ul>\n<table>\n<tbody>\n<tr>\n<td><\/td>\n<td colspan=\"2\"><strong> ESCALE, 2003-2004 <\/strong><\/td>\n<td colspan=\"2\"><strong> ESTELLE, 2010-2011 <\/strong><\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><strong> Interviews<\/strong><\/td>\n<td><strong> DNA<\/strong><\/td>\n<td><strong> Interviews<\/strong><\/td>\n<td><strong> DNA<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Leukemias<\/strong><\/td>\n<td>  764<\/td>\n<td>723<\/td>\n<td>746<\/td>\n<td>  707<\/td>\n<\/tr>\n<tr>\n<td><strong>Lymphomas<\/strong><\/td>\n<td>  295<\/td>\n<td>257<\/td>\n<td>  344<\/td>\n<td>  317<\/td>\n<\/tr>\n<tr>\n<td><strong>Brain tumors<\/strong><\/td>\n<td>  209<\/td>\n<td>176<\/td>\n<td>  302<\/td>\n<td>  254<\/td>\n<\/tr>\n<tr>\n<td><strong>Neurobastomes<\/strong><\/td>\n<td>  191<\/td>\n<td>  154<\/td>\n<td>  200<\/td>\n<td>  166<\/td>\n<\/tr>\n<tr>\n<td><strong>Nephroblastomas<\/strong><\/td>\n<td>  &#8211;<\/td>\n<td>  &#8211;<\/td>\n<td>  119<\/td>\n<td>  106<\/td>\n<\/tr>\n<tr>\n<td><strong>Hepatoblastomas<\/strong><\/td>\n<td>  &#8211;<\/td>\n<td>  &#8211;<\/td>\n<td>  22<\/td>\n<td>  19<\/td>\n<\/tr>\n<tr>\n<td><strong>Witnesses<\/strong><\/td>\n<td><strong>1681<\/strong><\/td>\n<td><strong>810<\/strong><\/td>\n<td><strong>1421<\/strong><\/td>\n<td><strong>894<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Regulatory aspects<\/strong><\/p>\n<ul>\n<li><strong>ESCALE<\/strong> CNIL n\u00b0902162 \u2013 RBM (DGS 2003\/0259)<\/li>\n<li><strong>ESTELLE <\/strong> CNIL n\u00b0908283 \u2013 hors RBM -CPP Ile de France IV, 2008\/12NICB<\/li>\n<\/ul>\n<p><strong>Financing <\/strong><\/p>\n<ul>\n<li><strong>ESCALE <\/strong>Fondation de France, ARC, AFSSAPS, Cent pour Sang la Vie, Inserm, AFSSET, ANR, INCA<\/li>\n<li><strong>ESTELLE <\/strong> INCa, Ligue Nationale contre le Cancer, Enfants et Sant\u00e9, DHOS<\/li>\n<\/ul>\n<p><strong>Principal Investigators:<\/strong> Audrey Bonaventure and Jacqueline Clavel<\/p>\n<p><strong>Collaborations for genetic analyses:<\/strong> CNRGH\/CEA, Institut Pasteur Lille<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Both surveys were conducted a few years apart with similar protocols. Objectives The objective of these two studies was: to study the influence, on the risk of cancer in children, of the course of pregnancy, the characteristics of the child at birth, the child&#8217;s environment in utero or during childhood, and their lifestyle. to identify [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[348],"tags":[],"class_list":["post-4458","post","type-post","status-publish","format-standard","hentry","category-research-and-results"],"acf":[],"_links":{"self":[{"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/posts\/4458","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/comments?post=4458"}],"version-history":[{"count":0,"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/posts\/4458\/revisions"}],"wp:attachment":[{"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/media?parent=4458"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/categories?post=4458"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rnce.inserm.fr\/en\/wp-json\/wp\/v2\/tags?post=4458"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}