Temporal variations in the incidence rate of childhood cancer in mainland France, 2000-2016.

Diagnostic groups and subgroups

N

AAPC (%)

CI95%

p

I. Leukemias, myeloproliferative diseases, and myelodysplastic diseases

8 503

0.1

[-0.3;0.6]

0.51

I.a Lymphoid leukemias

6 678

0.3

[-0.2;0.8]

0.18

I.b Acute myeloid leukemias

1 231

-0.5

[-1.6;0.7]

0.43

II. Lymphomas and reticuloendothelial neoplasms

3 258

-0.4

[-1.1;0.3]

0.22

II.a Hodgkin lymphomas

1 480

0.5

[-0.5;1.6]

0.34

II.b Non-Hodgkin lymphomas (except Burkitt lymphomas)

983

-0.7

[-2.0;0.6]

0.29

II.c Burkitt lymphomas

788

-1.9

[-3.3;-0.5]

< 0.01

III. CNS and miscellaneous intracranial and intraspinal neoplasms

7 500

1.2

[0.7;1.7]

< 0.01

III.a Ependymomas and choroid plexus tumors

709

0.5

[-1.0;2.0]

0.52

III.b Astrocytomas

2 798

1.3

[0.5;2.0]

< 0.01

III.c Intracranial and intraspinal embryonal tumors

1 422

0.0

[-1.1;1.0]

0.96

III.d Other gliomas

1 017

0.5

[-0.7;1.8]

0.40

III.e Other specified intracranial and intraspinal neoplasms

1 436

3.2

[2.1;4.3]

< 0.01

IV. Neuroblastomas and other peripheral nervous cell tumors

2 404

-0.5

[-1.3;0.3]

0.20

IV.a Neuroblastomas and ganglioneuroblastomas

2 372

-0.5

[-1.4;0.3]

0.19

V. Retinoblastomas

849

-0.4

[-1.8;1.0]

0.57

VI. Renal tumors

1 637

-0.5

[-1.5;0.5]

0.29

VI.a Nephroblastomas and other nonepithelial renal tumors

1 583

-0.4

[-1.4;0.6]

0.41

VII. Hepatic tumors

304

1.8

[-0.5;4.2]

0.12

VII.a Hepatoblastomas

256

2.0

[-0.6;4.6]

0.13

VIII. Malignant bone tumors

1 422

0.4

[-0.7;1.5]

0.47

VIII.a Osteosarcomas

660

-0.2

[-1.8;1.3]

0.78

VIII.c Ewing tumors and related bone sarcomas

657

1.6

[0.0;3.2]

0.05

IX. Soft tissue and other extraosseous sarcomas

1 882

-0.1

[-1.1;0.8]

0.76

IX.a Rhabdomyosarcomas

1 019

0.0

[-1.3;1.2]

0.94

IX.b Fibrosarcomas, peripheral nerve sheath tumors, and other fibrous neoplasms

139

0.7

[-2.6;4.2]

0.68

IX.d Other specified soft tissue sarcomas

579

-0.5

[-2.2;1.1]

0.52

IX.e Unspecified soft tissue sarcomas

141

0.5

[-2.8;4.0]

0.76

X. Germ-cell tumors, trophoblastic tumors, and neoplasms of gonads

1 113

-0.9

[-2.1;0.2]

0.12

X.a Intracranial and intraspinal germ cell tumors

423

0.0

[-1.9;2.0]

0.99

X.b Malignant extracranial and extragonadal germ cell tumors

291

-2.1

[-4.4;0.2]

0.08

X.c Malignant gonadal germ cell tumors

369

-1.3

[-3.3;0.8]

0.21

XI. Other malignant epithelial neoplasms and malignant melanomas

1 024

1.4

[0.1;2.7]

0.03

XI.b Thyroid carcinomas

411

-1.3

[-3.3;0.6]

0.19

XI.d Malignant melanomas

186

-1.2

[-4.0;1.8]

0.44

XII. Other and unspecified malignant neoplasms

70

4.8

[-0.2;10.0]

0.06

All cancers (excluding Langherhans cell histiocytosis)

29 966

0.3

[0.0;0.5]

0.03

Langherhans cell histiocytosis

118

-1.0

[-4.6;2.7]

0.6

All cancers (including Langherhans cell histiocytosis)

30 084

0.3

[0.0;0.5]

0.03

AAPC: average annual percent change in incidence rate (estimated by Poisson regression model)